Ion channels are pore-forming membrane proteins that create a gated, water-filled pore to help establish and control voltage potential across cell membranes through control of the active flow of ions between the intracellular and the extracellular environments (Sharan et al. 2013). As key components in a wide variety of biological processes involved in rapid changes in cells (e.g. cardiac/skeletal/smooth muscle contraction, and epithelial transport of nutrients), ion channels are important therapeutic targets in a range of indications, including cardiac, CNS, immune system and metabolic diseases. Due to the development of screening technologies, a dramatically increased interest has been shown in ion channels for hit validation,
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